She is a part of fundraisers such as Fuck Cancer, Run For the Gulf, and Global Green Gulf Relief, and has been involved in political issues, including her support for Barack Obama as president in the 2008 election.
I thought, 'If I could do this for the rest of my life, I am set.' It was like love at first sight." Bush made her first big screen appearance in the 2002 film National Lampoon's Van Wilder opposite Ryan Reynolds.
Following this, she made appearances in several television shows, including Nip/Tuck, Sabrina the Teenage Witch, and the HBO film Point of Origin.
In 2003, Bush was cast as Kate Brewster in Terminator 3: Rise of the Machines, though she was replaced by Claire Danes after a week of filming.
In 2003, Bush landed the role of Brooke Davis in the WB television series One Tree Hill.
In July 2006, Bush co-starred in the 20th Century Fox comedy film John Tucker Must Die, directed by Betty Thomas, opposite Brittany Snow and Jesse Metcalfe.
The film was a commercial success, grossing over million worldwide.She has posed on the cover of several mainstream magazines such as Entertainment Weekly, Lucky, Maxim, Glamour, In Style, and Zooey Magazine.She has also had several endorsement deals, such as for Ocean Pacific clothing.That same year, she also starred in Buena Vista Pictures' supernatural thriller Stay Alive alongside Jon Foster, Frankie Muniz, and Adam Goldberg. She played Grace Andrews in the 2007 remake of the classic horror film The Hitcher, starring opposite Sean Bean.The film, the first to be released by Hollywood Pictures in five years, opened at number three in the U. In 2008, Bush co-starred alongside Kevin Zegers and Vincent D'Onofrio in François Velle's independent film The Narrows, playing the beautiful, intelligent, and self-assured Kathy Popovich.In February 2012, it was reported that Bush had joined the cast of the upcoming CBS sitcom Partners.