She received critical acclaim for her performance in the film, with noting, "Nayanthara is the surprise package of the film.
In 2010, she also made her Kannada film debut through the Kannada-Telugu bilingual film Super, her only appearance in a Kannada film to date.
Her portrayal of Sita in Sri Rama Rajyam (2011) earned her the Filmfare Award for Best Telugu Actress and the Nandi Award for Best Actress.
Sify wrote: "Nayanthara virtually walks away with the film and has never looked so beautiful.
She looks gorgeous especially in songs and does justice to her well-etched out role".
The latter three, in particular, were particularly good for Nayanthara, with Simha becoming one of the highest-grossing Telugu films of the year and Boss Engira Bhaskaran releasing to positive reviews, and becoming a financial success.
Her only release in 2011 was the mythological film Sri Rama Rajyam(2011) by Bapu, in which she played the role of Sita.She gave a fine understated performance conveying a kaleidoscope of emotions." She portrayed the role of a journalist and her performance was praised, with a reviewer from Sify stating that "Nayanthara does not play the normal commercial glam-doll for a change and she is good" and "her chemistry with Rana is perfect".The following year, she won critical acclaim for her performance in Atlee's romantic drama Raja Rani (2013), winning both the Filmfare and Vijay Award for Best Actress.Manassinakkare went on to become a high financial success and she continued to receive acting offers.Both her releases in 2004, Natturajavu by Shaji Kailas, and Fazil's psychological thriller Vismayathumbathu, saw her co-starring alongside Mohanlal; while she played the protagonist's adopted sister in the former, she portrayed a ghost in the latter. Nayanthara subsequently started appearing in Tamil and Telugu films.Her subsequent releases were Kuselan, Sathyam, Villu and Aegan . In 2010, all her releases, which featured her as the female lead, turned out to be commercial successes: she had five box office hits in the four Southern languages – Adhurs (Telugu) Bodyguard (Malayalam), Simha (Telugu), Boss Engira Bhaskaran (Tamil) and Super (Kannada, Telugu).