He has appeared as several real-life individuals, including Charlie Chaplin in The Cat's Meow, actor Gustav von Wangenheim in Shadow of the Vampire and General Erich Fellgiebel in Valkyrie. Kite in Across the Universe, Lussurioso in Revengers Tragedy and criminal expert Roman Nagel in Ocean's Twelve and Ocean's Thirteen.
In 1995, he portrayed the title character in Christopher Marlowe's Edward II.In 1998 Izzard appeared briefly on stage with the Monty Python team in The American Film Institute's Tribute to Monty Python (also referred to as Monty Python Live at Aspen).He had a starring role in the television series The Riches as Wayne Malloy and has appeared in films such as Ocean's Twelve, Ocean's Thirteen, Mystery Men, Shadow of the Vampire, The Cat's Meow, Across the Universe and Valkyrie.He has also worked as a voice actor in The Wild, Igor, The Chronicles of Narnia: Prince Caspian, Cars 2 and The LEGO Batman Movie.In June 2010, Izzard replaced James Spader in the role of Jack Lawson in David Mamet's play Race on Broadway.
Izzard has appeared in numerous films, starting with 1996's The Secret Agent.
Izzard portrayed comedian Lenny Bruce in the 1999 production of Julian Barry's 1971 play Lenny.
In 2001, he replaced Clive Owen in Peter Nichols' 1967 play A Day in the Death of Joe Egg at the Comedy Theatre.
appeared again in a party political broadcast for the 2009 European election, and again in a 2010 election video entitled Brilliant Britain.
Izzard appeared in literature to support changing the British electoral system from first-past-the-post to alternative vote for electing Members of Parliament to the House of Commons in the Alternative Vote referendum in 2011.
Izzard has cited his main comedy role model as Monty Python, and John Cleese once referred to him as the "Lost Python".